Tổng hợp y văn: Acid folic cải thiện chức năng nhận thức ở người cao tuổi




Chức năng nhận thức suy giảm theo tuổi tác do nồng độ axit amin homocysteine ​​trong máu cao. Điều này có thể dẫn đến chứng mất trí nhớ và / hoặc bệnh Alzheimer.

 Axit folic từ lâu đã được biết đến với vai trò trong việc ngăn ngừa khuyết tật ống thần kinh ở trẻ sơ sinh. Tuy nhiên, nghiên cứu gần đây chứng minh rằng vitamin B cho thấy hứa hẹn ở phổ tuổi khi về già. Các nhà nghiên cứu đã tiến hành đánh giá tác dụng của axit folic đối với chức năng nhận thức ở người cao tuổi. Trong nghiên cứu, 818 người tham gia với độ tuổi từ 50 đến 70 tuổi, được bổ sung 800 mcg axit folic hoặc giả dược trong 3 năm. Tất cả những người tham gia có mức homocysteine ​​cao và mức folate thấp khi bắt đầu nghiên cứu. Kết luận của nghiên cứu, những người được bổ sung axit folic cho thấy mức folate tăng lên tới 576% và giảm mức homocysteine ​​là 26%. Họ cũng cho thấy sự cải thiện lớn về chức năng bộ nhớ và tốc độ xử lý thông tin. Ngoài ra, họ có mức giảm thính lực cao hơn theo thời gian so với nhóm giả dược.

Literature Review: Folic Acid Improves Cognitive Function in the Elderly

Durga et al. Effects of folic acid supplementation on hearing in older adults: a randomized, double blind, controlled trial. Ann Intern Med. 2007;146:1-9.

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial

Published:January 20, 2007DOI:https://doi.org/10.1016/S0140-6736(07)60109-3
Figure. No caption a... - Click to enlarge in new window Figure. No caption available.

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. The Lancet. 2007; 369:208-216.

Cognitive functions decline with age due to higher levels of the amino acid homocysteine in the blood. This can lead to dementia and/or Alzheimer’s disease.

Folic acid has long been known for its role in the prevention of neural-tube defects in newborns. However, recent research demonstrates that vitamin B shows promise on the other end of the age spectrum. These researchers conducted an examination of the effect of folic acid on cognitive function in the elderly. In the study, 818 people, 50 to 70 years of age, were either given an 800 mcg folic acid supplement or a placebo over 3 years. All participants had high homocysteine levels and low folate levels at the beginning of the study. At the study’s conclusion, the people who received the folic acid supplements showed increased folate levels of 576%, and decreased homocysteine levels of 26%. They also showed vast improvement in memory function and the speed of information processing. In addition, they had a higher decline of hearing loss over time than the placebo group.



Low folate and raised homocysteine concentrations in blood are associated with poor cognitive performance in the general population. As part of the FACIT trial to assess the effect of folic acid on markers of atherosclerosis in men and women aged 50–70 years with raised plasma total homocysteine and normal serum vitamin B12 at screening, we report here the findings for the secondary endpoint: the effect of folic acid supplementation on cognitive performance.


Our randomised, double blind, placebo controlled study took place between November, 1999, and December, 2004, in the Netherlands. We randomly assigned 818 participants 800 μg daily oral folic acid or placebo for 3 years. The effect on cognitive performance was measured as the difference between the two groups in the 3-year change in performance for memory, sensorimotor speed, complex speed, information processing speed, and word fluency. Analysis was by intention-to-treat. This trial is registered withclinicaltrials.gov with trial number NCT00110604.


Serum folate concentrations increased by 576% (95% CI 539 to 614) and plasma total homocysteine concentrations decreased by 26% (24 to 28) in participants taking folic acid compared with those taking placebo. The 3-year change in memory (difference in Z scores 0·132, 95% CI 0·032 to 0·233), information processing speed (0·087, 0·016 to 0·158) and sensorimotor speed (0·064, −0·001 to 0·129) were significantly better in the folic acid group than in the placebo group.


Folic acid supplementation for 3 years significantly improved domains of cognitive function that tend to decline with age.


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